Careers within the Blackhorn Network

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Staff Systems Engineer



Software Engineering
San Francisco, CA, USA
Posted on Monday, March 13, 2023

Headquartered in San Francisco, CA, Cytovale is a dynamic, late-stage startup focused on developing a faster, more insightful way to diagnose fast-moving and immune-mediated diseases. Cytovale’s IntelliSep test is pioneering a new way of quickly and accurately analyzing white blood cells to stratify a patient’s risk of sepsis. The test simply and clearly determines risk of sepsis using a biomechanical evaluation of white blood cells collected from a standard blood draw, generating results in under 10 minutes. This gives physicians actionable information when they need it most, allowing them to confidently triage suspected sepsis patients quickly and spend more time with those in greatest need. It also helps strained health systems prevent unnecessary treatment, preserve valuable resources, and improve compliance with Sep-1 guidelines.

More information at and watch our IntelliSep video!


The Staff Systems Engineering will be a key architect for Cytovale’s next generation instrumentation. They will work closely with other New Product Development Engineers (Mechanical, Software, Electrical, and Test) to design an integrated instrument with enhanced user experience through the incorporation of automation and DFX features. The position will work closely with internal and external collaborators to integrate next generation instrumentation hardware, software, and test activities. This position will work cross-functionally to align hardware and software development, draft and refine system requirements and risk documentation, and facilitate phase-in on DFX activities based on input from manufacturing, service, and human factors. This role reports to senior engineering leadership.


  • Plan hardware, software, and test integration activities.
  • Lead drafting and maintenance of requirement and risk documents (ISO 14971) within Cytovale’s quality system (ISO 13485).
  • Establish and maintain traceability between design inputs and outputs.
  • Incorporate DFX feedback from key internal and external partners within manufacturing, service, and human factors.
  • Collaborate with the New Product Development team to realize an improved and more reliable instrument design. Key partners include Mechanical, Software, Electrical Engineering, and Quality Assurance.
  • Interface directly with design partners and contract manufacturers to facilitate effective completion of engineering activities.
  • Provide input on key architecture and documentation strategy decisions based on previous experience in the IVD or medical device space. Maintain project plans, budgets, and sprint plans throughout the development process.
  • Support human factors and GUI development based on customer feedback.
  • Coordination verification and validation activities.


  • Bachelor's Degree in Mechanical Engineering, Biomedical Engineering, or a related Science/Engineering field with 7+ years of experience with complex electromechanical instrumentation. Desired: 5+ medical device or regulated product development design experience, or equivalent industry experience.
  • Successful history of supporting a product from feasibility through product launch within a 21 CFR Part 820 compliant quality management system.
  • Extensive knowledge of complex fluidic electro-mechanical systems.
  • Familiarity with quantitative hardware test development and verification activities.
  • Experience applying concurrent design principles during feasibility and development.
  • Familiarity with software testing and verification activities,, including automated and regression testing.
  • Preferred: Proficiency programming experience in Python, Labview, and/or C++.
  • Prefered: Knowledge of instrument electrical architectures and best practices to develop instruments to meet IEC 60601-1-2 and IEC 61010 EMC/EMC standards.


  • This position will be based in the San Francisco Bay Area.
  • Ability to work in the United States.
  • Role is up to 4 days per week onsite to carry out role functions. Up to 20% domestic travel.

Who you are

  • Excellent communicator, detail-oriented, and an avid GDP/GLP laboratory practitioner
  • Fast-learner with a “can-do” attitude and an ability to work independently.
  • Desire to work in a high velocity startup where collaboration is prized.
  • You have a passion for our mission and believe that what we are building is innovative enough to change the world.
  • You thrive in a fluid environment, are comfortable with ambiguity and can shift gears quickly.

At Cytovale, we are an extraordinary team of biologists, data scientists, engineers, quality, clinical and just plain caring people with a vision for how to make very complex, critical diseases come into sharp and present focus. We will never stop working together and striving to make our technology stronger, faster, and easier-to-implement so that every person who arrives for medical care is quickly screened and appropriately treated for fast-moving diseases while there is still time to act.

Cytovale offers a total rewards package that includes a generous base salary, annual cash bonus based on corporate and individual goal attainment, and an equity stake in the organization. We have a mandatory COVID-19 vaccination policy, casual work environment, a diverse and inclusive culture, and an electric atmosphere for professional development. Qualified applicants will receive consideration without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, gender expression, veteran status, or disability.